Immunomodulatory effect of Mesenchymal Stem Cells on B cells

Immunomodulatory effect of Mesenchymal Stem Cells on B cells

Blog Article

The research on T cell immunosuppression therapies has attracted most of the attention in clinical transplantation.However, B cells and humoral immune responses are increasingly acknowledged as crucial mediators of chronic allograft rejection.Indeed, humoral immune responses can lead to renal allograft rejection even in patients whose cell-mediated immune responses are well controlled.On the other hand, newly studied Antibactrerial Wipes B cell subsets with regulatory effects have been linked to tolerance achievement in transplantation.

Better understanding of the regulatory and effector B cell responses may therefore lead to new therapeutic approaches.Mesenchymal Stem Cells Straw Dispensers/Holders (MSC) are arising as a potent therapeutic tool in transplantation due to their regenerative and immunomodulatory properties.The research on MSCs has mainly focused on their effects on T cells and although data regarding the modulatory effects of MSCs on alloantigen-specific humoral response in humans is scarce, it has been demonstrated that MSCs significantly affect B cell functioning.In the present review we will analyze and discuss the results in this field.